Research Interests

My work primarily focuses on epigenetics, chromatin structure, and disease, using molecular biology, genetics, biochemistry and animal models. My lab studies the human neurodevelopmental disorder Williams Syndrome, and particularly the role of the chromatin remodeling subunit Williams Syndrome Transcription Factor (WSTF), using the clawed frog Xenopus laevis as a model. In addition, my lab studies the roles of histone modifications in DNA repair and both nuclear and mitochondrial genome stability.

Publications

Textbooks

• Krebs, J.E., E.S. Goldstein and S.T. Kilpatrick (2011). Lewin’s GENES X. Jones and Bartlett Publishers, Boston. ISBN-13 978076376632 http://www.jblearning.com/catalog/9780763766320/
• Krebs, J.E., E.S. Goldstein and S.T. Kilpatrick (2009). Lewin’s Essential GENES, 2nd Edition. Jones and Bartlett Publishers, Boston. ISBN-13 9780733759155 http://www.jblearning.com/catalog/9780763759155/

Papers

• Yazgan, O. and J.E. Krebs (2012). Mitochondrial and nuclear genomic integrity after oxidative damage in Saccharomyces cerevisiae. Front Biosci. 2012 Jan 1;17:1079-1093.
• Barnett, C. and J.E. Krebs (2011). WSTF does it all: a multifunctional protein in transcription, repair and replication. Biochemistry and Cell Biology 89(1):12-23.
• Harrison, B., Yazgan, O. and J.E. Krebs (2009). Life without RNAi: Non-coding RNAs and their functions in S. cerevisiae. Biochemistry and Cell Biology 87(5):767-79.
• Humpal, S., D. A. Robinson and J. E. Krebs (2008). Marks to stop the clock: Histone modifications and checkpoint regulation in the DNA damage response. Biochemistry and Cell Biology 87(1): 243-53.
• Krebs, J. E. (2007). Moving marks: Dynamic histone modifications in yeast. Molecular Biosystems 3(9):590-7.
• Yazgan, O. and J. E. Krebs (2007). Non-coding but non-expendable: transcriptional regulation by large noncoding RNA in eukaryotes. Biochemistry and Cell Biology 85(4): 484-96.
• Brown, E., S. Malakar and J. E. Krebs (2007). How many remodelers does it take to make a brain? Diverse and cooperative roles of ATP-dependent remodeling complexes in development. Biochemistry and Cell Biology 85(4):444-62.
• Moore, J. D., O. Yazgan, Y. Ataian and J. E. Krebs (2007). Diverse roles for histone H2A modifications in different DNA damage response pathways. Genetics 176: 15-25.
• Papamichos-Chronakis, M., J. E. Krebs and C. L. Peterson (2006). Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptation in response to DNA damage. Genes & Development 20:2437-2449.
• Ataian, Y. and J. E. Krebs (2006). Five repair pathways in one context: chromatin modification during DNA repair. Biochemistry and Cell Biology 84(4): 409-504.
• Uffenbeck, S. G. and J. E. Krebs (2006). The role of chromatin structure in regulating stress-induced transcription in Saccharomyces cerevisiae. Biochemistry and Cell Biology 84(4): 477-489. 
• Dirscherl, S.S., J. J. Henry and J. E. Krebs (2005). Neural and eye-specific defects associated with loss of the Imitation Switch (ISWI) chromatin remodeler in Xenopus laevis. Mechanisms of Development 122(11): 1157-1170. 
• Kuo, Hui-Ching, J.D. Moore and J.E. Krebs (2005). Histone H2A and Spt10 cooperate to regulate induction and autoregulation of the CUP1 metallothionein. Journal of Biological Chemistry 280(1): 104-111. 
• Dirscherl, S.S. and J.E. Krebs (2004). Functional diversity of ISWI remodeling complexes. Biochemistry and Cell Biology 82(4): 482-489. 
• Moore, J.D. and J.E. Krebs (2004). Histone modifications and double strand break repair. Biochemistry and Cell Biology 82(4): 446-452. 
• Jaskelioff, M., S. Van Komen, J. E. Krebs, P. Sung, and C. L. Peterson (2003). Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatin. Journal of Biological Chemistry, 278 (11): 9212-9218. 
• Krebs, J. E., C. J. Fry, M. Samuels and C. L. Peterson (2000). A global role for chromatin remodeling in mitotic gene expression. Cell 102: 587-598. 
• Krebs, J. E. and C. L. Peterson (2000). Understanding "active" chromatin: A historical perspective of chromatin remodeling. Critical Reviews in Eukaryotic Gene Expression 10(1): 1-12. 
• Krebs, J. E., M.-H. Kuo, C. D. Allis and C. L. Peterson (1999). Cell cycle-regulated histone acetylation required for expression of the yeast HO gene. Genes & Development 13: 1412-1421. 
• Krebs, J. E. and M. Dunaway (1998). The scs and scs’ insulator elements impart a cis requirement on enhancer-promoter interactions. Molecular Cell 1(2): 301-308. 
• Krebs, J. E. and M. Dunaway (1996). DNA length is a critical parameter for eukaryotic transcription in vivo. Molecular and Cellular Biology 16: 5821-5829.

Career History/Work Experience

Director, Alaska IDeA Network of Biomedical Research Excellence