Lauren Kohntopp, M.S. candidate in biological sciences, will present 'Copper chelation and zinc supplementation induce sex-specific metabolomics responses in a treatment model of the Atp7b-/- Wilson Disease mouse' on March 31.

Summary

Wilson Disease (WD) is an autosomal recessive disease caused by a mutation to the ATP7B gene resulting in abnormal levels of copper accumulated in the brain, liver and other vital organs. Metabolic pathways affected by WD and related treatments are not entirely defined, nor is copper’s effect on zinc homeostasis. Additionally, sex and genotype differences in the WD metabolome are not often examined. To investigate these pathways and dissimilarities in WD, male and female KO (Atp7p-/-) mice and WTH (Atp7b-/+,+/+)  mice were separated into experimental groups using WD treatments: bis-choline tetrathiomolybdate (TTM) and zinc acetate. Liver tissue and blood serum were collected after 8 weeks of consecutive treatment for analysis and analyzed via NMR, LC-MS, and ICP-MS. Collectively, the results of this study provide a deeper understanding of the mechanisms that underlie the loss of Atp7b copper transportation and the effect of monotherapies TTM and zinc acetate.

Event details

Event location - LIB 307 and Zoom
Event date - March 31, 2025
Event start time - 12 p.m.
Event end time - 1 p.m.

Zoom link

 

March Archive